diff --git a/vendor/magento/framework/DB/Adapter/Pdo/Mysql.php b/vendor/magento/framework/DB/Adapter/Pdo/Mysql.php
index fc84dcafc4688..21a56d72f8792 100644
--- a/vendor/magento/framework/DB/Adapter/Pdo/Mysql.php
+++ b/vendor/magento/framework/DB/Adapter/Pdo/Mysql.php
@@ -432,6 +432,12 @@ private function avoidReusingParentProcessConnection()
             $this->parentConnections[] = $this->_connection;
             $this->_connection = null;
             $this->pid = getmypid();
+
+            // Reset config host to avoid issue with multiple connections
+            if (!empty($this->_config['port']) && strpos($this->_config['host'], ':') === false) {
+                $this->_config['host'] = implode(':', [$this->_config['host'], $this->_config['port']]);
+                unset($this->_config['port']);
+            }
         }
     }